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Many fans went online to. Web alcohol intolerance can cause immediate, uncomfortable reactions after you drink alcohol. Web markiplier cannot drink alcohol because he has a condition called a liver biotransformation deficiency, which. Web in episode #145 of the less stressed life podcast, i talk about a few of the factors that reduce our tolerance to alcohol like the. Being unable to limit the amount of alcohol you drink. Web signs and symptoms may include: Web markiplier said that he no longer drinks alcohol as the risk of another heart attack isn’t worth it. Wanting to cut down on how much. Web he did drink alcohol, though sparingly, for a while (hence why he has drunk minecraft) but after a heart attack, where his heart.