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Combining alcohol with accutane can pose additional risks. Web can you drink alcohol on accutane? Web consuming alcohol while on accutane may place additional strain on the liver, potentially leading to increased liver toxicity. Accutane and alcohol should not be mixed without checking with your. Web can you drink alcohol on accutane? Alcohol and accutane (isotretinoin) interaction can be. Web potential risks of combining alcohol and accutane. Web drinking alcohol with accutane isn’t recommended because it can increase your risk of side effects.