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You should avoid drinking while taking trazodone. This is because both trazodone and alcohol are central nervous. Why is it bad to mix antidepressants and alcohol? Drinking alcohol before bed has been shown to. When alcohol is combined with trazodone, the risks can be intensified. It's best to avoid combining antidepressants. Web products and services. Web [1] unfortunately, alcohol has the potential to limit trazodone’s wanted effects and emphasize its unwanted effects. Alcohol can make you sleepy or drowsy and make it dangerous to drive,. But waiting at least 2 days after your last dose is safest. Web you may be able to drink alcohol after you’ve stopped taking trazodone. Web can you take trazodone with alcohol? It is critical to avoid alcohol when.