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Web show them a complete list of all of your medicines. Web tramadol and alcohol both slow down central nervous system activity. Web taking tramadol in combination with alcohol and other substances that depress the central nervous system. Web tramadol, an opioid, should be avoided with alcohol due to an increased risk of side effects, including the risk of a. Mixing substances can intensify both. Web mixing alcohol and tramadol can increase the calming and euphoric effects of both drugs, but it also amplifies.