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Web consuming more than is recommended by the current u.s. Web it's best to avoid combining antidepressants and alcohol. It may worsen your symptoms, and it can be dangerous. I'm on pristiq and i'm not sure whether it's safe. Web it should not be used with alcohol due to a risk for dangerous sedation or unconsciousness. On sertraline, i can basically drink all night. Alcohol is actually a brain depressant. Alcohol also interferes with the metabolism of antidepressants,. Web specifically snris like pristiq or effexor. Dietary guidelines for alcohol — two drinks or less. Web drinking alcohol while taking antidepressants can enhance the above side effects and cause additional reactions.