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Web can you drink alcohol while on macrobid? What are the effects of drinking alcohol while. While there are no known direct interaction between nitrofurantoin and. Drinking alcohol in moderation is. Web drinking alcohol in moderation is generally considered safe while taking macrobid for a urinary tract infection (uti). Alcohol can interfere with the absorption of macrobid into the bloodstream, which can reduce the. Web alcohol can interfere with the effectiveness of macrobid, an antibiotic commonly prescribed to treat urinary tract infections. Web there are no known interactions between alcohol and nitrofurantoin and drinking on macrobid is safe, but definitely not. Web since nitrofurantoin is also known as macrobid, the same guidelines apply.