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Web drinking alcohol with accutane isn’t recommended because it can increase your risk of side effects. Web can you drink alcohol on accutane? Web here are three key areas to consider when it comes to the dangers of drinking alcohol while on accutane:. Alcohol and accutane (isotretinoin) interaction can be. Web by simone sydel | licensed esthetician. Due to its strength and side effects, many are wondering about the lifestyle changes.